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Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

The Journal of clinical investigation, 2018-04, Vol.128 (4), p.1208-1216

2018

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Cellular senescence in aging and age-related disease: from mechanisms to therapy

Nature medicine, 2015-12, Vol.21 (12), p.1424-1435

2015

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Cellular Senescence and the Immune System in Cancer

Gerontology (Basel), 2019-01, Vol.65 (5), p.505-512

2019

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Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Science (American Association for the Advancement of Science), 2016-10, Vol.354 (6311), p.472-477

2016

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Senescence and apoptosis: dueling or complementary cell fates?

EMBO reports, 2014-11, Vol.15 (11), p.1139-1153

2014

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Untangling senescent and damage‐associated microglia in the aging and diseased brain

The FEBS journal, 2023-03, Vol.290 (5), p.1326-1339

2023

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Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Stroke (1970), 2016-04, Vol.47 (4), p.1068-1077

2016

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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Diabetes (New York, N.Y.), 2016-06, Vol.65 (6), p.1606-1615

2016

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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

The EMBO journal, 2014-07, Vol.33 (13), p.1438-1453

2014

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p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

Cell reports (Cambridge), 2013-04, Vol.3 (4), p.1164-1174

2013

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Senescent cells limit p53 activity via multiple mechanisms to remain viable

Nature communications, 2022-06, Vol.13 (1), p.3722-3722, Article 3722

2022

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Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

Cancer cell, 2009-12, Vol.16 (6), p.475-486

2009

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Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

Nature cell biology, 2013-01, Vol.15 (1), p.96

2013

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ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (32), p.14188-14193

2010

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Probing the depths of cellular senescence

The Journal of cell biology, 2013-07, Vol.202 (1), p.11-13

2013

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Spartan deficiency causes genomic instability and progeroid phenotypes

Nature communications, 2014-12, Vol.5 (1), p.5744-5744, Article 5744

2014

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Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

The Journal of cell biology, 2007-10, Vol.179 (2), p.255-267

2007

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Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

PloS one, 2019-10, Vol.14 (10), p.e0224172-e0224172

2019

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Hyperphosphorylated PTEN exerts oncogenic properties

Nature communications, 2023-05, Vol.14 (1), p.2983-2983, Article 2983

2023

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

PLoS genetics, 2012-12, Vol.8 (12), p.e1003138

2012

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

Nature genetics, 2004-07, Vol.36 (7), p.744-749

2004

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BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

The Journal of clinical investigation, 2020-01, Vol.130 (1), p.171-188

2020

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p21 induces a senescence program and skeletal muscle dysfunction

Molecular metabolism (Germany), 2023-01, Vol.67, p.101652-101652, Article 101652

2023

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Insights from In Vivo Studies of Cellular Senescence

Cells (Basel, Switzerland), 2020-04, Vol.9 (4), p.954

2020

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Nature (London), 2018-10, Vol.562 (7728), p.578-582

2018

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Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Cellular Senescence and the Immune System in Cancer

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Senescence and apoptosis: dueling or complementary cell fates?

Untangling senescent and damage‐associated microglia in the aging and diseased brain

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

Senescent cells limit p53 activity via multiple mechanisms to remain viable

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

Probing the depths of cellular senescence

Spartan deficiency causes genomic instability and progeroid phenotypes

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

Hyperphosphorylated PTEN exerts oncogenic properties

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

p21 induces a senescence program and skeletal muscle dysfunction

Insights from In Vivo Studies of Cellular Senescence

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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