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Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation

Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1345-1361

2019

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Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

Pharmacological reviews, 2016-01, Vol.68 (1), p.168-241

2016

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In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors

Drug metabolism and disposition, 2014-07, Vol.42 (7), p.1202

2014

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Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review

PloS one, 2019-04, Vol.14 (4), p.e0216029

2019

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Pharmacokinetic Comparison of the Potential Over-the-Counter Statins Simvastatin, Lovastatin, Fluvastatin and Pravastatin

Clinical pharmacokinetics, 2008-01, Vol.47 (7), p.463-474

2008

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Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

Drug metabolism and disposition, 2019-04, Vol.47 (4), p.377-385

2019

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Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers

American journal of respiratory and critical care medicine, 2009-06, Vol.179 (12), p.1107-1114

2009

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Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters

Expert opinion on drug metabolism & toxicology, 2017-01, Vol.13 (1), p.83-95

2017

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Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function

Clinical and translational science, 2024-03, Vol.17 (3), p.e13773-n/a

2024

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Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response

Drug metabolism and disposition, 2013-01, Vol.41 (1), p.50

2013

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Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

Journal of cachexia, sarcopenia and muscle, 2018-04, Vol.9 (2), p.417-432

2018

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Cytochrome P450 in Pharmacogenetics: An Update

Advances in pharmacology (1990), 2018, Vol.83, p.3

2018

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Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

Clinical and translational science, 2020-03, Vol.13 (2), p.345-351

2020

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Trimethoprim and the CYP2C83 allele have opposite effects on the pharmacokinetics of pioglitazone

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.73

2008

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Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

Clinical science (1979), 2017-04, Vol.131 (8), p.747

2017

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The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study

Atherosclerosis plus, 2024-03, Vol.55, p.93-97

2024

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Pharmacogenomics of celiprolol – evidence for a role of P‐glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics

Clinical and translational science, 2022-02, Vol.15 (2), p.409-421

2022

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Voriconazole greatly increases the exposure to oral buprenorphine

European journal of clinical pharmacology, 2018-12, Vol.74 (12), p.1615-1622

2018

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Healthcare costs and mortality associated with serious fluoroquinolone‐related adverse reactions

Pharmacology research & perspectives, 2022-04, Vol.10 (2), p.e00931-n/a

2022

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Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations

Drug metabolism and disposition, 2011-05, Vol.39 (5), p.904

2011

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The effect of hydroxychloroquine on cholesterol metabolism in statin treated patients after myocardial infarction

Atherosclerosis plus, 2023-09, Vol.53, p.26-32

2023

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Itraconazole, a P-Glycoprotein and CYP3A4 Inhibitor, Markedly Raises the Plasma Concentrations and Enhances the Renin-Inhibiting Effect of Aliskiren

Journal of clinical pharmacology, 2011-03, Vol.51 (3), p.359-367

2011

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Effects of the SLCO1B11B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

Pharmacogenetics and genomics, 2008-11, Vol.18 (11), p.937-942

2008

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Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

European journal of clinical pharmacology, 2015-03, Vol.71 (3), p.321-327

2015

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Performance of Plasma Coproporphyrin I and III as OATP1B1 Biomarkers in Humans

Clinical pharmacology and therapeutics, 2021-12, Vol.110 (6), p.1622-1632

2021

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Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors

Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review

Pharmacokinetic Comparison of the Potential Over-the-Counter Statins Simvastatin, Lovastatin, Fluvastatin and Pravastatin

Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters

Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function

Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response

Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

Cytochrome P450 in Pharmacogenetics: An Update

Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

Trimethoprim and the CYP2C83 allele have opposite effects on the pharmacokinetics of pioglitazone

Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study

Pharmacogenomics of celiprolol – evidence for a role of P‐glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics

Voriconazole greatly increases the exposure to oral buprenorphine

Healthcare costs and mortality associated with serious fluoroquinolone‐related adverse reactions

Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations

The effect of hydroxychloroquine on cholesterol metabolism in statin treated patients after myocardial infarction

Itraconazole, a P-Glycoprotein and CYP3A4 Inhibitor, Markedly Raises the Plasma Concentrations and Enhances the Renin-Inhibiting Effect of Aliskiren

Effects of the SLCO1B11B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

Performance of Plasma Coproporphyrin I and III as OATP1B1 Biomarkers in Humans

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