Details

Autor(en) / Beteiligte

• Gong, Leilei
• Zhu, Yun
• Xu, Xi
• Li, Huaiqin
• Guo, Weimin
• Zhao, Qin
• Yao, Dengbing

Titel

The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury

Ist Teil von

• Neural regeneration research, 2014-12, Vol.9 (24), p.2151-2158

Ort / Verlag

India: Medknow Publications and Media Pvt. Ltd

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration （0-4 days） in rats with sciatic nerve injury, but the mechanism underlying this process remains poorly understood. This study reported the effects of claudin 14 on nerve degeneration and regeneration during early Wallerian degeneration. Claudin 14 expression was up-regulated in sciatic nerve 4 days after Wallerian degeneration. The altered expression of claudin 14 in Schwann cells resulted in expression changes of cytokines in vitro. Expression of claudin 14 affected c-Jun, but not Akt anal ERK1/2 patl~ways, l~urther studies reve~ed that enhanced expression of claudin 14 could promote Schwann cell proliferation and migration. Silencing of claudin 14 expression resulted in Schwann cell apoptosis and reduction in Schwann cell proliferation. Our data revealed the role of claudin 14 in early Wallerian degeneration, which may provide new insights into the molecular mechanisms of Wallerian degeneration.