Details

Autor(en) / Beteiligte

• YANG, Otto O
• BOSCARDIN, W. John
• SHEARER, Gene M
• GRENE, Edith
• CARRINGTON, Mary
• O'BRIEN, Steve
• PRICE, Charles B
• DETELS, Roger
• JAMIESON, Beth D
• GIORGI, Janis V
• MATUD, Jose
• HAUSNER, Mary Ann
• HULTIN, Lance E
• HULTIN, Patricia M
• SHIH, Roger
• FERBAS, John
• SIEGAL, Frederick P
• SHODELL, Michael

Titel

Immunologic profile of highly exposed yet HIV type 1-seronegative men

Ist Teil von

• AIDS research and human retroviruses, 2002-09, Vol.18 (14), p.1051-1065

Ort / Verlag

Larchmont, NY: Liebert

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• The host immune factors that determine susceptibility to HIV-1 infection are poorly understood. We compared multiple immunologic parameters in three groups of HIV-1-seronegative men: 14 highly exposed (HR10), 7 previously reported possibly to have sustained transient infection (PTI), and a control group of 14 low risk blood bank donors (BB). Virus-specific cellular immune assays were performed for CD4(+) T helper cell responses, CD8(+) cytotoxic T lymphocyte activity, CD8(+) cell chemokine release, and CD8(+) cell-derived antiviral soluble factor activity. General immune parameters evaluated included CCR5 genotype and phenotype, interferon alpha production by PBMCs, leukocyte subset analysis, and detailed T lymphocyte phenotyping. Comparisons revealed no detectable group-specific differences in measures of virus-specific immunity. However, the HR10 group differed from the BB group in several general immune parameters, having higher absolute monocyte counts, higher absolute CD8(+) T cell counts and percentages, lower naive and higher terminal effector CD8(+) cells, and lower levels of CD28(+)CD8(+) cells. These changes were not associated with seropositivity for other chronic viral infections. The PTI men appeared to have normal levels of monocytes and slightly elevated levels of CD8(+) T cells (also with increased effector and decreased naive cells). Although we cannot entirely exclude the contribution of other chronic viral infections, these findings suggest that long-lived systemic cellular antiviral immunity as detected by our assays is not a common mechanism for resistance to infection, and that resistance may be multifactorial. General immune parameters reflected by CD8(+) T cell levels and activation, and monocyte concentrations may affect the risk of infection with HIV-1, and/or serve as markers of exposure.