Autor(en)
Shen, Xianyan; Zhou, Qiang; Xiong, Wei; Pu, Wenchen; Zhang, Wei; Zhang, Guolin; Wang, Chun
Titel
Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication
Teil von
  • Tetrahedron, 10 August 2017, Vol.73(32), pp.4822-4829
Links zum Volltext
Beschreibungen
Herein, we report a synthetic method with improved selectivity for 5-substituted flavonols via the Algar-Flynn-Oyamada reaction (AFO), by using of sodium carbonate/hydrogen peroxide A series of 5-substituted flavonols was obtained with moderate to high yields. The mechanism of the AFO reaction was elucidated. LCMS analysis and in situ 1H NMR analysis indicated that the epoxide was involved in the transformation from chalcone to flavonol and/or aurone under alkaline base/peroxide conditions. An efficient method for synthesis of 5-substituted flavonol was provided. The mechanism of Algar-Flynn-Oyamada reaction (AFO) was elucidated by LCMS study and in situ NMR analysis. [Display omitted]
Format
Sprache(n)
Englisch
Identifikator(en)
ISSN: 0040-4020
ISSN: 1464-5416
DOI: 10.1016/j.tet.2017.06.064
Links zum Inhalt
Schlagwörter
Flavonol, Synthesis, Afo, Mechanism, Flavonol, Synthesis, Afo, Mechanism, Chemistry
Systemstelle
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