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Signal flow and pathways in response to early Wallerian degeneration after rat sciatic nerve injury
Ist Teil von
Neuroscience letters, 2013-03, Vol.536, p.56-63
Ort / Verlag
Ireland: Elsevier Ireland Ltd
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
► Analyzed signal flows and pathways of early Wallerian Degeneration (WD). ► Explore the key regulate factors and recurrent neural networks in the process of early WD. ► Reported some key factors, which may play a powerful role in regulating gene expressions during early WD.
Wallerian degeneration (WD) remains a subject of critical research interest in modern neurobiology. WD is a process which a large number of genes are differentially regulated, especially the early response to activate nerve degeneration and regeneration, but the precise mechanisms remain elusive. In this study, we report the signal pathways, key regulate recurrent neural networks and signal flow in the early WD. The data indicated that there are several kinds of up- or down-regulated genes, relating to the regulation of response to stimulus, signal transmission via phosphorylation event, immune response, apoptosis and regulation of cell communication. KEGG pathway analysis revealed activity mainly relating to cytokine–cytokine receptor interaction, MAPK signaling pathway, Jak-STAT signaling pathway, ErbB signaling pathway and TGF-beta signaling pathway involved in the recurrent neural networks that were regulated by the key factors, Cldn-14, Cldn-15, ITG, BID and BIRC3. These results will help to much better understand information relating to the early response to WD and provide us with a firmer basis in future investigations on the molecular mechanisms of WD that regulate nerve degeneration and/or regeneration.