Details

Autor(en) / Beteiligte

• Wang, Shiyang
• Fan, Xiaobing
• Medved, Milica
• Pineda, Federico D
• Yousuf, Ambereen
• Oto, Aytekin
• Karczmar, Gregory S

Titel

Arterial input functions (AIFs) measured directly from arteries with low and standard doses of contrast agent, and AIFs derived from reference tissues

Ist Teil von

• Magnetic resonance imaging, 2016-02, Vol.34 (2), p.197-203

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Measurements of arterial input function (AIF) can have large systematic errors at standard contrast agent doses in dynamic contrast enhanced MRI (DCE-MRI). We compared measured AIFs from low dose (AIFLD ) and standard dose (AIFSD ) contrast agent injections, as well as the AIF derived from a muscle reference tissue and artery (AIFref ). Twenty-two prostate cancer patients underwent DCE-MRI. Data were acquired on a 3 T scanner using an mDixon sequence. Gadobenate dimeglumine was injected twice, at doses of 0.015 and 0.085 mmol/kg. Directly measured AIFs were fitted with empirical mathematical models (EMMs) and compared to the AIF derived from a muscle reference tissue (AIFref ). EMMs accurately fitted the AIFs. The 1st and 2nd pass peaks were visualized in AIFLD , but not in AIFSD , thus the peak and shape of AIFSD could not be accurately measured directly. The average scaling factor between AIFSD and AIFLD in the washout phase was only 56% of the contrast dose ratio (~ 6:1). The shape and magnitude of AIFref closely approximated that of AIFLD after empirically determined dose-dependent normalization. This suggests that AIFref may be a good approximation of the local AIF.