Torvela, Tiina; Lähde, Anna; Mönkäre, Juha; Riikonen, Joakim; Lehtinen, Kari E.J; Järvinen, Kristiina; Lehto, Vesa-Pekka; Jokiniemi, Jorma; Joutsensaari, Jorma
Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers
Teil von
  • Journal of aerosol science, 2011, Vol.42(10), pp.645-656
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Nanoparticles can be used to improve the delivery of many drugs, especially peptides and proteins. Although several methods are available for polymeric nanoparticle preparation, there are few single-stage processes that produce dry, solid nanoparticles that can be easily re-dispersed in pharmaceutical vehicles. The aerosol flow reactor method is a single-stage process that has been used for the preparation of multicomponent, coated nanoparticles under uniform temperature and gas flow field. However, it is traditionally used with high synthesis temperatures. In the present study, the aerosol flow reactor method was further optimized for processing and surface stabilization of pharmaceutical nanoparticles containing temperature sensitive biomolecules. In the developed method, drug-loaded carrier nanoparticles consisting of a biodegradable polymer (Eudragit L100) and a drug (phenylephrine hydrochloride) were first produced by aerosol droplet drying and subsequently coated in the...
ISSN: 0021-8502
ISSN: 1879-1964
DOI: 10.1016/j.jaerosci.2011.06.006

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