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LOW IN-TREATMENT HDL CHOLESTEROL LEVELS STRONGLY PREDICT SUDDEN CARDIAC DEATH IN HYPERTENSIVE PATIENTS: THE LIFE STUDY
Ist Teil von
Journal of the American College of Cardiology, 2012-03, Vol.59 (13), p.E1626-E1626
Ort / Verlag
New York: Elsevier Inc
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
In multivariate Cox analyses adjusting for randomized treatment, age, sex, body mass index, prevalent and history of atrial fibrillation and diabetes, history of MI, ischemic heart disease, stroke, peripheral vascular disease, smoking status, baseline serum creatinine, glucose, urine albumin/creatinine ratio as standard risk factors and for statin use, incident MI, in-treatment diastolic and systolic pressure, heart rate, QRS duration, Cornell product criteria for left ventricular hypertrophy and non-HDL cholesterol levels as time-varying covariates, the lowest quartile of in-treatment HDL remained associated with a 49% greater risk of SCD (95% CI 6-109%, p=0.022) and, in alternative analyses, each 1 SD lower HDL treated as a continuous variable remained predictive of a 39% higher risk of SCD (95% CI 11-75%, p=0.004).