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A simple vortex-assisted graphene oxide nanosheets dispersive micro-solid phase extraction combined with high-performance liquid chromatography for UV-Vis detection of tramadol in biological samples
Ist Teil von
Separation science and technology, 2018-07, Vol.53 (11), p.1689-1697
Ort / Verlag
Abingdon: Taylor & Francis Ltd
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
This study developed a simple, rapid and sensitive method that utilizes vortex-assisted graphene oxide nanosheets dispersive micro-solid phase extraction of tramadol hydrochloride from biological samples. The data obtained from scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy confirmed the characteristics of graphene oxide nanosheets (GONSs). In order to increase the extraction efficiency, a vortex was applied in the extraction process. In this study, parameters affecting the extraction efficiency were identified and discussed. The optimal experimental parameters were as follows: pH, amount of GONSs, type and volume of desorption solvent, vortexing time, and addition of NaCl. Under optimized conditions, this method allowed the determination of tramadol in the range of 5-300 µg l-1 and the limit of detection was 0.16 µg l-1. The intra-day and inter-day precisions obtained were 2.4% and 3.8%, respectively. This method can be used as an analytical technique for the determination of tramadol in biological samples.