Dermatologic clinics, 2018-07, Vol.36 (3), p.189-197
2018
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Details
- Autor(en) / Beteiligte
- Titel
- Prurigo Nodularis and Its Management
- Ist Teil von
- Dermatologic clinics, 2018-07, Vol.36 (3), p.189-197
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Prurigo nodularis occurs with chronic pruritus and the presence of single to multiple symmetrically distributed, hyperkeratotic, and intensively itching nodules. Diverse dermatologic, systemic, neurologic, or psychiatric conditions can lead to prurigo nodularis. Structural analysis demonstrated a reduced intraepidermal nerve fiber density and increased dermal levels of nerve growth factor and neuropeptides such as substance P and calcitonin gene-related peptide. Novel therapy concepts such as inhibitors at neurokinin-1, opioid receptors, and interleukin-31 receptors have been developed. The mainstays of prurigo nodularis therapy comprise topical steroids, capsaicin, calcineurin inhibitors, phototherapy, and the systemic application of anticonvulsants, μ-opioid receptor antagonists, or immunosuppressants.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0733-8635eISSN: 1558-0520DOI: 10.1016/j.det.2018.02.003Titel-ID: cdi_crossref_primary_10_1016_j_det_2018_02_003
- Format
- –
- Schlagworte
- Algorithms, Antidepressive Agents - therapeutic use, Antipruritics - therapeutic use, Calcineurin Inhibitors - therapeutic use, Calcium Channel Blockers - therapeutic use, Glucocorticoids - therapeutic use, Humans, Immunosuppressive Agents - therapeutic use, Mental Disorders - complications, Narcotic Antagonists - therapeutic use, Nervous System Diseases - complications, Prurigo - etiology, Prurigo - physiopathology, Prurigo - therapy, Pruritus - etiology, PUVA Therapy