Details

Autor(en) / Beteiligte

• Allander, Tobias
• Beyene, Aster
• Jacobson, Stefan H.
• Grillner, Lena
• Persson, Mats A. A.

Titel

Patients Infected with the Same Hepatitis C Virus Strain Display Different Kinetics of the Isolate-Specific Antibody Response

Ist Teil von

• The Journal of infectious diseases, 1997-01, Vol.175 (1), p.26-31

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1997

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The antibody response to the hypervariable region of the E2 protein (HVR1) of hepatitis C virus (HCV) was studied in 5 patients who were infected by a common virus strain during an outbreak in a hemodialysis unit. Two patients resolved the infection, while 3 developed chronic HCV infection. For studying the antibody response to HVRl during the early phase of infection, a Western blot assay using recombinant phage displaying HVRl was developed. The 2 patients with resolving infection had a more rapid antibody response to HVRl than did the patients developing chronic infection. Anti-HVR1 antibodies were repeatedly absent in 1 of the chronically infected patients. Antibodies to recombinant E2 protein occurred later than the anti-HVR1 antibodies and did not correlate with resolution of the infection. Thus, the present results suggest that early appearance of antibodies to the HVRl may predict clearance of HCV infection.