Clinical and experimental pharmacology & physiology, 2021-05, Vol.48 (5), p.637-650
2021
Details
- Autor(en) / Beteiligte
- Titel
- Role of the SphK‐S1P‐S1PRs pathway in invasion of the nervous system by SARS‐CoV‐2 infection
- Ist Teil von
- Clinical and experimental pharmacology & physiology, 2021-05, Vol.48 (5), p.637-650
- Ort / Verlag
- Australia: Wiley Subscription Services, Inc
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- Wiley Online Library (Online service)
- Beschreibungen/Notizen
- Global spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is still ongoing. Before an effective vaccine is available, the development of potential treatments for resultant coronavirus disease 2019 (COVID‐19) is crucial. One of the disease hallmarks is hyper‐inflammatory responses, which usually leads to a severe lung disease. Patients with COVID‐19 also frequently suffer from neurological symptoms such as acute diffuse encephalomyelitis, brain injury and psychiatric complications. The metabolic pathway of sphingosine‐1‐phosphate (S1P) is a dynamic regulator of various cell types and disease processes, including the nervous system. It has been demonstrated that S1P and its metabolic enzymes, regulating neuroinflammation and neurogenesis, exhibit important functions during viral infection. S1P receptor 1 (S1PR1) analogues including AAL‐R and RP‐002 inhibit pathophysiological responses at the early stage of H1N1 virus infection and then play a protective role. Fingolimod (FTY720) is an S1P receptor modulator and is being tested for treating COVID‐19. Our review provides an overview of SARS‐CoV‐2 infection and critical role of the SphK‐S1P‐SIPR pathway in invasion of SARS‐CoV‐2 infection, particularly in the central nervous system (CNS). This may help design therapeutic strategies based on the S1P‐mediated signal transduction, and the adjuvant therapeutic effects of S1P analogues to limit or prevent the interaction between the host and SARS‐CoV‐2, block the spread of the SARS‐CoV‐2, and consequently treat related complications in the CNS.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0305-1870, 1440-1681eISSN: 1440-1681DOI: 10.1111/1440-1681.13483Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_145981278
- Format
- –
- Schlagworte
- ACE2, Adaptor Proteins, Signal Transducing - genetics, Adaptor Proteins, Signal Transducing - metabolism, Antiviral Agents - pharmacology, Brain, Brain injury, Cellular signal transduction, Central nervous system, Complications, Coronaviridae, Coronaviruses, COVID-19, COVID-19 - drug therapy, COVID-19 - pathology, cytokine storm, Encephalomyelitis, Enzymes, Fingolimod, FTY720, Head injuries, Health aspects, Humans, immuno‐modulators, Infections, Injuries, Lung diseases, Medical treatment, Medicin och hälsovetenskap, Metabolic pathways, Metabolism, Nervous system, Neurogenesis, Phosphates, Receptors, Respiratory diseases, Review, SARS-CoV-2, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Signal transduction, Signs and symptoms, Sphingosine 1 Phosphate Receptor Modulators - pharmacology, sphingosine 1‐phosphate, Sphingosine-1-Phosphate Receptors - genetics, Sphingosine-1-Phosphate Receptors - metabolism, Vaccines, Viral diseases, Virus diseases, Viruses