Details

Autor(en) / Beteiligte

• Maertens, Johan
• Cesaro, Simone
• Maschmeyer, Georg
• Einsele, Hermann
• Donnelly, J Peter
• Alanio, Alexandre
• Hauser, Philippe M
• Lagrou, Katrien
• Melchers, Willem J G
• Helweg-Larsen, Jannik
• Matos, Olga
• Bretagne, Stéphane
• Cordonnier, Catherine

Titel

ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients

Ist Teil von

• Journal of antimicrobial chemotherapy, 2016-09, Vol.71 (9), p.2397-2404

Ort / Verlag

England: Oxford University Press (OUP)

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based on the grading system of the IDSA. Trimethoprim/sulfamethoxazole given 2-3 times weekly is the drug of choice for the primary prophylaxis of PCP in adults ( A-II: ) and children ( A-I: ) and should be given during the entire period at risk. Recent data indicate that children may benefit equally from a once-weekly regimen ( B-II: ). All other drugs, including pentamidine, atovaquone and dapsone, are considered second-line alternatives when trimethoprim/sulfamethoxazole is poorly tolerated or contraindicated. The main indications of PCP prophylaxis are ALL, allogeneic HSCT, treatment with alemtuzumab, fludarabine/cyclophosphamide/rituximab combinations, >4 weeks of treatment with corticosteroids and well-defined primary immune deficiencies in children. Additional indications are proposed depending on the treatment regimen.