Details

Autor(en) / Beteiligte

• Besbas, N.
• Karpman, D.
• Landau, D.
• Loirat, C.
• Proesmans, W.
• Remuzzi, G.
• Rizzoni, G.
• Taylor, C.M.
• Van de Kar, N.
• Zimmerhackl, L.B.

Titel

A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders

Ist Teil von

• Kidney international, 2006-08, Vol.70 (3), p.423-431

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2006

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the causes of the syndrome now permit many patients to be classified according to etiology. The increased precision of a diagnosis based on causation is important for considering logical approaches to treatment and prognosis. It is also essential for research. We propose a classification that accommodates both a current understanding of causation (level 1) and clinical association in cases for whom cause of disease is unclear (level 2). We tested the classification in a pediatric disease registry of HUS. The revised classification is a stimulus to comprehensive investigation of all cases of HUS and TTP and is expected to increase the proportion of cases in whom a level 1 etiological diagnosis is confirmed.