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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Ist Teil von
Science (American Association for the Advancement of Science), 2016-11, Vol.354 (6313), p.751-757
Ort / Verlag
United States: American Association for the Advancement of Science
Erscheinungsjahr
2016
Link zum Volltext
Quelle
American Association for the Advancement of Science
Beschreibungen/Notizen
Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.