Details

Autor(en) / Beteiligte

• Chen, Shuo-Bin
• Wu, Wei-Bin
• Hu, Ming-Hao
• Ou, Tian-Miao
• Gu, Lian-Quan
• Tan, Jia-Heng
• Huang, Zhi-Shu

Titel

Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexesElectronic supplementary information (ESI) available: Synthesis and characterization of IZCM-1, experimental procedures, and supplemental spectra and graphs. See DOI: 10.1039/c4cc05394j

Erscheinungsjahr

2014-09

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A novel 2,4,5-triaryl-substituted imidazole (IZCM-1) has been found to display distinct and specific fluorescence enhancement upon binding to parallel G-quadruplexes. Such a sensitive and topology-specific probe is able to light up without affecting the topology or thermal stability of the G-quadruplex sample. Thus, these advantages distinguish IZCM-1 from other G-quadruplex probes. A sensitive probe was developed for the detection of parallel G-quadruplexes without affecting their topology or thermal stability.