Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
JAKs and STATs in Immunity, Immunodeficiency, and Cancer
Ist Teil von
The New England journal of medicine, 2013-01, Vol.368 (2), p.161-170
Ort / Verlag
Waltham, MA: Massachusetts Medical Society
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
A large number of cytokines signal through the JAK–STAT pathway. Abnormal function of this pathway may lead to a variety of diseases. Targeting the defects in this signaling pathway has already led to treatment advances, and further advances are likely.
This past year marked the 20th anniversary of the discovery of the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway.
1
Arising from efforts to understand the molecular mechanisms of interferon action, the elucidation of this pathway has provided many insights into disease mechanisms and has become the basis for new pharmacologic agents. It is therefore an appropriate time to take stock of our knowledge of this pathway and to consider the ways in which these insights are affecting the practice of medicine.
Cytokines and JAK–STAT Signaling
Interferons, erythropoietin, growth hormone, and prolactin, all discovered more than half a . . .