Details

Autor(en) / Beteiligte

• Gadziola, Marie A.
• Stetzik, Lucas A.
• Wright, Katherine N.
• Milton, Adrianna J.
• Arakawa, Keiko
• del Mar Cortijo, María
• Wesson, Daniel W.

Titel

A Neural System that Represents the Association of Odors with Rewarded Outcomes and Promotes Behavioral Engagement

Ist Teil von

• Cell reports (Cambridge), 2020-07, Vol.32 (3), p.107919-107919, Article 107919

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Electronic Journals Library - Freely accessible e-journals

Beschreibungen/Notizen

• Odors are well known to elicit strong emotional and behavioral responses that become strengthened throughout learning, yet the specific cellular systems involved in odor learning and the direct influence of these on behavior are unclear. Here, we investigate the representation of odor-reward associations within two areas recipient of dense olfactory input, the posterior piriform cortex (pPCX) and the olfactory tubercle (OT), using electrophysiological recordings from mice engaged in reward-based learning. Neurons in both regions represent conditioned odors and do so with similar information content, yet the proportion of neurons recruited by conditioned rewarded odors and the magnitudes and durations of their responses are greater in the OT. Using fiber photometry, we find that OT D1-type dopamine-receptor-expressing neurons flexibly represent odors based on reward associations, and using optogenetics, we show that these neurons influence behavioral engagement. These findings contribute to a model whereby OT D1 neurons support odor-guided motivated behaviors. [Display omitted] •Ensembles from both the OT and pPCX accurately encode conditioned odors•More OT neurons represent rewarded odors and do so in manners different from pPCX•OT D1 neurons flexibly represent rewarded odors during reversal learning•Activation of OT D1 neurons promotes engagement in a reinforcer-motivated task Gadziola et al. show that while both posterior piriform cortex (pPCX) and olfactory tubercle (OT) neurons accurately encode learned reinforced odors, OT neurons differ from those in the pPCX by how the encoding occurs. Further, OT D1 neurons flexibly represent conditioned rewarded odors, and their activation promotes behavioral engagement.