Details

Autor(en) / Beteiligte

• Jais, Alexander
• Paeger, Lars
• Sotelo-Hitschfeld, Tamara
• Bremser, Stephan
• Prinzensteiner, Melanie
• Klemm, Paul
• Mykytiuk, Vasyl
• Widdershooven, Pia J.M.
• Vesting, Anna Juliane
• Grzelka, Katarzyna
• Minère, Marielle
• Cremer, Anna Lena
• Xu, Jie
• Korotkova, Tatiana
• Lowell, Bradford B.
• Zeilhofer, Hanns Ulrich
• Backes, Heiko
• Fenselau, Henning
• Wunderlich, F. Thomas
• Kloppenburg, Peter
• Brüning, Jens C.

Titel

PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding

Ist Teil von

• Neuron (Cambridge, Mass.), 2020-06, Vol.106 (6), p.1009-1025.e10

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Calorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice activates prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus of the hypothalamus (ARC). PNOCARC neurons represent a previously unrecognized GABAergic population of ARC neurons distinct from well-defined feeding regulatory AgRP or POMC neurons. PNOCARC neurons arborize densely in the ARC and provide inhibitory synaptic input to nearby anorexigenic POMC neurons. Optogenetic activation of PNOCARC neurons in the ARC and their projections to the bed nucleus of the stria terminalis promotes feeding. Selective ablation of these cells promotes the activation of POMC neurons upon HFD exposure, reduces feeding, and protects from obesity, but it does not affect food intake or body weight under normal chow consumption. We characterize PNOCARC neurons as a novel ARC neuron population activated upon palatable food consumption to promote hyperphagia. [Display omitted] •Acute high-fat-diet feeding activates PNOC neurons in the arcuate nucleus (ARC)•GABAergic PNOCARC neurons inhibit anorexigenic POMC neurons•Optogenetic activation of PNOCARC neurons promotes feeding•Ablation of PNOCARC neurons protects from obesity Calorie-rich diets induce hyperphagia and promote obesity. Here, Jais et al. report that short-term high-fat-diet (HFD) feeding in mice activates prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus of the hypothalamus (ARC). They characterize PNOCARC neurons as a novel ARC neuron population activated upon palatable food consumption to promote hyperphagia.