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Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review
Movement disorders, 2019-02, Vol.34 (2), p.180-198
Seppi, Klaus
Ray Chaudhuri, K.
Coelho, Miguel
Fox, Susan H.
Katzenschlager, Regina
Perez Lloret, Santiago
Weintraub, Daniel
Sampaio, Cristina
Chahine, Lana
Hametner, Eva‐Maria
Heim, Beatrice
Lim, Shen‐Yang
Poewe, Werner
Djamshidian‐Tehrani, Atbin
2019
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Seppi, Klaus
Ray Chaudhuri, K.
Coelho, Miguel
Fox, Susan H.
Katzenschlager, Regina
Perez Lloret, Santiago
Weintraub, Daniel
Sampaio, Cristina
Chahine, Lana
Hametner, Eva‐Maria
Heim, Beatrice
Lim, Shen‐Yang
Poewe, Werner
Djamshidian‐Tehrani, Atbin
Titel
Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review
Ist Teil von
Movement disorders, 2019-02, Vol.34 (2), p.180-198
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2019
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
ABSTRACT Objective To update evidence‐based medicine recommendations for treating nonmotor symptoms in Parkinson's disease (PD). Background The International Parkinson and Movement Disorder Society Evidence‐Based Medicine Committee's recommendations for treatments of PD were first published in 2002, updated in 2011, and now updated again through December 31, 2016. Methods Level I studies testing pharmacological, surgical, or nonpharmacological interventions for the treatment of nonmotor symptoms in PD were reviewed. Criteria for inclusion and quality scoring were as previously reported. The disorders covered were a range of neuropsychiatric symptoms, autonomic dysfunction, disorders of sleep and wakefulness, pain, fatigue, impaired olfaction, and ophthalmologic dysfunction. Clinical efficacy, implications for clinical practice, and safety conclusions are reported. Results A total of 37 new studies qualified for review. There were no randomized controlled trials that met inclusion criteria for the treatment of anxiety disorders, rapid eye movement sleep behavior disorder, excessive sweating, impaired olfaction, or ophthalmologic dysfunction. We identified clinically useful or possibly useful interventions for the treatment of depression, apathy, impulse control and related disorders, dementia, psychosis, insomnia, daytime sleepiness, drooling, orthostatic hypotension, gastrointestinal dysfunction, urinary dysfunction, erectile dysfunction, fatigue, and pain. There were no clinically useful interventions identified to treat non‐dementia‐level cognitive impairment. Conclusions The evidence base for treating a range of nonmotor symptoms in PD has grown substantially in recent years. However, treatment options overall remain limited given the high prevalence and adverse impact of these disorders, so the development and testing of new treatments for nonmotor symptoms in PD remains a top priority. © 2019 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185, 1531-8257
eISSN: 1531-8257
DOI: 10.1002/mds.27602
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6916382
Format
–
Schlagworte
Anxiety
,
Anxiety Disorders - therapy
,
Autonomic nervous system
,
Clinical trials
,
Cognition Disorders - epidemiology
,
Cognitive ability
,
Dementia
,
Dementia disorders
,
Depression - therapy
,
Emotional behavior
,
Erectile dysfunction
,
Evidence-Based Medicine
,
Fatigue
,
Gastrointestinal diseases
,
Humans
,
Hypotension
,
Impulsive behavior
,
MDS Commissioned Review
,
Mental disorders
,
Movement disorders
,
Neurodegenerative diseases
,
non‐motor symptoms
,
Olfaction
,
Pain
,
Parkinson Disease - therapy
,
Parkinson's disease
,
Psychosis
,
randomized controlled trial
,
REM sleep
,
Saliva
,
Sleep and wakefulness
,
Sleep disorders
,
Sweating
,
Treatment Outcome
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