Details

Autor(en) / Beteiligte

• Wiesen, Daniel
• Sperber, Christoph
• Yourganov, Grigori
• Rorden, Christopher
• Karnath, Hans-Otto

Titel

Using machine learning-based lesion behavior mapping to identify anatomical networks of cognitive dysfunction: Spatial neglect and attention

Ist Teil von

• NeuroImage (Orlando, Fla.), 2019-11, Vol.201, p.116000-116000, Article 116000

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Previous lesion behavior studies primarily used univariate lesion behavior mapping techniques to map the anatomical basis of spatial neglect after right brain damage. These studies led to inconsistent results and lively controversies. Given these inconsistencies, the idea of a wide-spread network that might underlie spatial orientation and neglect has been pushed forward. In such case, univariate lesion behavior mapping methods might have been inherently limited in detecting the presumed network due to limited statistical power. By comparing various univariate analyses with multivariate lesion-mapping based on support vector regression, we aimed to validate the network hypothesis directly in a large sample of 203 newly recruited right brain damaged patients. If the exact same correction factors and parameter combinations (FDR correction and dTLVC for lesion size control) were used, both univariate as well as multivariate approaches uncovered the same complex network pattern underlying spatial neglect. At the cortical level, lesion location dominantly affected the temporal cortex and its borders into inferior parietal and occipital cortices. Beyond, frontal and subcortical gray matter regions as well as white matter tracts connecting these regions were affected. Our findings underline the importance of a right network in spatial exploration and attention and specifically in the emergence of the core symptoms of spatial neglect. •We used SVR-LSM and VLBM in 203 right brain damaged patients to examine the lesion-behavior relationship of spatial neglect.•Findings underline the importance of a right complex network pattern underlying the core symptoms of spatial neglect.•Multivariate and univariate lesion analysis techniques might come to the same topographical conclusions.