Details

Autor(en) / Beteiligte

• Haas, Carola A
• Dudeck, Oliver
• Kirsch, Matthias
• Huszka, Csaba
• Kann, Gunda
• Pollak, Stefan
• Zentner, Josef
• Frotscher, Michael

Titel

Role for Reelin in the Development of Granule Cell Dispersion in Temporal Lobe Epilepsy

Ist Teil von

• The Journal of neuroscience, 2002-07, Vol.22 (14), p.5797-5802

Ort / Verlag

United States: Soc Neuroscience

Erscheinungsjahr

2002

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• The reelin signaling pathway plays a crucial role during the development of laminated structures in the mammalian brain. Reelin, which is synthesized and secreted by Cajal-Retzius cells in the marginal zone of the neocortex and hippocampus, is proposed to act as a stop signal for migrating neurons. Here we show that a decreased expression of reelin mRNA by hippocampal Cajal-Retzius cells correlates with the extent of migration defects in the dentate gyrus of patients with temporal lobe epilepsy. These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy.