Details

Autor(en) / Beteiligte

• Behnke, Kristina
• Zhuang, Yuan
• Xu, Haifeng C.
• Sundaram, Balamurugan
• Reich, Maria
• Shinde, Prashant V.
• Huang, Jun
• Modares, Nastaran Fazel
• Tumanov, Alexei V.
• Polz, Robin
• Scheller, Jürgen
• Ware, Carl F.
• Pfeffer, Klaus
• Keitel, Verena
• Häussinger, Dieter
• Pandyra, Aleksandra A.
• Lang, Karl S.
• Lang, Philipp A.

Titel

B Cell‐Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration

Ist Teil von

• Hepatology (Baltimore, Md.), 2018-12, Vol.68 (6), p.2348-2361

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• The liver has an extraordinary capacity to regenerate through activation of key molecular pathways. However, central regulators controlling liver regeneration remain insufficiently studied. Here, we show that B cell–deficient animals failed to induce sufficient liver regeneration after partial hepatectomy (PHx). Consistently, adoptive transfer of B cells could rescue defective liver regeneration. B cell–mediated lymphotoxin beta production promoted recovery from PHx. Absence of B cells coincided with loss of splenic cluster of differentiation 169–positive (CD169+) macrophages. Moreover, depletion of CD169+ cells resulted in defective liver regeneration and decreased survival, which was associated with reduced hepatocyte proliferation. Mechanistically, CD169+ cells contributed to liver regeneration by inducing hepatic interleukin‐6 (IL‐6) production and signal transducer and activator of transcription 3 activation. Accordingly, treatment of CD169+ cell–depleted animals with IL‐6/IL‐6 receptor rescued liver regeneration and severe pathology following PHx. Conclusion: We identified CD169+ cells to be a central trigger for liver regeneration, by inducing key signaling pathways important for liver regeneration.