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The Parsortix™ Cell Separation System—A versatile liquid biopsy platform
Cytometry. Part A, 2018-12, Vol.93 (12), p.1234-1239
Miller, M. Craig
Robinson, Peggy S.
Wagner, Christopher
O'Shannessy, Daniel J.
2018
Details
Autor(en) / Beteiligte
Miller, M. Craig
Robinson, Peggy S.
Wagner, Christopher
O'Shannessy, Daniel J.
Titel
The Parsortix™ Cell Separation System—A versatile liquid biopsy platform
Ist Teil von
Cytometry. Part A, 2018-12, Vol.93 (12), p.1234-1239
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Electronic Journals Library - Freely accessible e-journals
Beschreibungen/Notizen
Cancer cells from solid tumors can enter the circulatory system and survive to subsequently form distant metastases. The CellSearch® system (Menarini‐Silicon Biosystems, Huntingdon Valley, PA) was the first, FDA‐cleared system that provided a reliable tool for the investigation of circulating tumor cells (CTCs), which have been shown to be strongly associated with poor survival and therapy failure. Since that time, a number of new technologies have been introduced to improve CTC detection and/or isolation for further characterization. The continued and growing interest in the “liquid biopsy” field has spurred the development of numerous different CTC technologies. However, selecting the most appropriate CTC platform for individual applications can be challenging. No consensus has yet been reached in the community regarding which liquid biopsy technology is optimal. Here, we introduce the Parsortix™ Cell Separation System (ANGLE North America, Inc., King of Prussia, PA), a microfluidic based technology that captures rare cells based on size and deformability, offers reproducibly high capture efficiency, and produces highly enriched, viable (viability dependent on preservative used) CTCs that are amenable to a multitude of downstream analyses, including the isolation and interrogation of single cells. © 2018 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4922
eISSN: 1552-4930
DOI: 10.1002/cyto.a.23571
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6586069
Format
–
Schlagworte
Biopsy
,
Cancer
,
Cell Count - methods
,
Cell Line, Tumor
,
Cell Separation - methods
,
Cell Size
,
circulating tumor cell
,
Circulatory system
,
CTC Technologies and Tools
,
Cytometry
,
Deformability
,
Deformation
,
Formability
,
Humans
,
Interrogation
,
liquid biopsy
,
Liquid Biopsy - methods
,
MCF-7 Cells
,
Metastases
,
Microfluidics
,
Microfluidics - methods
,
Neoplastic Cells, Circulating - pathology
,
New technology
,
rare cell isolation
,
Separation
,
Solid tumors
,
Tumor cells
,
Tumors
,
Viability
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