Details

Autor(en) / Beteiligte

• Shinotoh, Hitoshi
• Shimada, Hitoshi
• Kokubo, Yasumasa
• Tagai, Kenji
• Niwa, Fumitoshi
• Kitamura, Soichiro
• Endo, Hironobu
• Ono, Maiko
• Kimura, Yasuyuki
• Hirano, Shigeki
• Mimuro, Maya
• Ichise, Masanori
• Sahara, Naruhiko
• Zhang, Ming-Rong
• Suhara, Tetsuya
• Higuchi, Makoto

Titel

Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula

Ist Teil von

• Neurology, 2019-01, Vol.92 (2), p.e136

Ort / Verlag

United States

Erscheinungsjahr

2019

Link zum Volltext

Beschreibungen/Notizen

• To characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [ C]PBB3 as ligand. This is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Thirteen healthy men (69 ± 6 years) participated as healthy controls (HCs). Dynamic PET scans were performed following injection of [ C]PBB3, and parametric PET images were generated by voxel-by-voxel calculation of binding potential ( ) using a multilinear reference tissue model. [ C] Pittsburgh compound B (PiB) PET, MRI, and cognitive tests were also performed. A voxel-based comparison of [ C]PBB3 illustrated PET-detectable tau deposition in the cerebral cortex and white matter, and pontine basis including the corticospinal tract in Kii ALS/PDC patients compared with HCs (uncorrected < 0.05). Group-wise volume of interest analysis of [ C]PBB3 images showed increased in the hippocampus and in frontal and parietal white matters of Kii ALS/PDC patients relative to HCs ( < 0.05, Holm-Sidak multiple comparisons test). in frontal, temporal, and parietal gray matters correlated with Mini-Mental State Examination scores in Kii ALS/PDC patients ( < 0.05). All Kii ALS/PDC patients were negative for [ C]PiB (β-amyloid) except one with marginal positivity. [ C]PBB3 PET visualized the characteristic topography of tau pathology in Kii ALS/PDC, corresponding to clinical phenotypes of this disease.