Cerebral cortex (New York, N.Y. 1991), 2017-05, Vol.27 (5), p.2841-2856
2017
Details
- Autor(en) / Beteiligte
- Titel
- Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells
- Ist Teil von
- Cerebral cortex (New York, N.Y. 1991), 2017-05, Vol.27 (5), p.2841-2856
- Ort / Verlag
- United States: Oxford University Press
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- A unique population of cells, called "lot cells," circumscribes the path of the lateral olfactory tract (LOT) in the rodent brain and acts to restrict its position at the lateral margin of the telencephalon. Lot cells were believed to originate in the dorsal pallium (DP). We show that Lhx2 null mice that lack a DP show a significant increase in the number of mGluR1/lot cells in the piriform cortex, indicating a non-DP origin of these cells. Since lot cells present common developmental features with Cajal-Retzius (CR) cells, we analyzed Wnt3a- and Dbx1-reporter mouse lines and found that mGluR1/lot cells are not generated in the cortical hem, ventral pallium, or septum, the best characterized sources of CR cells. Finally, we identified a novel origin for the lot cells by combining in utero electroporation assays and histochemical characterization. We show that mGluR1/lot cells are specifically generated in the lateral thalamic eminence and that they express mitral cell markers, although a minority of them express ΔNp73 instead. We conclude that most mGluR1/lot cells are prospective mitral cells migrating to the accessory olfactory bulb (OB), whereas mGluR1+, ΔNp73+ cells are CR cells that migrate through the LOT to the piriform cortex and the OB.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1047-3211eISSN: 1460-2199DOI: 10.1093/cercor/bhw126Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6248457
- Format
- –
- Schlagworte
- Animals, Cell Movement, Cells, Cultured, Embryo, Mammalian, Female, Gene Expression Regulation, Developmental - physiology, Homeodomain Proteins - genetics, Homeodomain Proteins - metabolism, LIM-Homeodomain Proteins - genetics, LIM-Homeodomain Proteins - metabolism, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Mice, Transgenic, Nerve Tissue Proteins - metabolism, Neurogenesis - physiology, Original, Pregnancy, Receptors, Metabotropic Glutamate - genetics, Receptors, Metabotropic Glutamate - metabolism, Stem Cells - physiology, T-Box Domain Proteins - metabolism, Thalamus - cytology, Thalamus - metabolism, Transcription Factors - genetics, Transcription Factors - metabolism, Tumor Protein p73 - genetics, Tumor Protein p73 - metabolism