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Association between Exposure to p,p '-DDT and Its Metabolite p,p '-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Ist Teil von
Environmental health perspectives, 2017-09, Vol.125 (9), p.096002
Ort / Verlag
United States: National Institute of Environmental Health Sciences
Erscheinungsjahr
2017
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
The prevalence of obesity is increasing in all countries, becoming a substantial public health concern worldwide. Increasing evidence has associated obesity with persistent pollutants such as the pesticide DDT and its metabolite
'-DDE.
Our objective was to systematically review the literature on the association between exposure to the pesticide DDT and its metabolites and obesity to develop hazard identification conclusions.
We applied a systematic review-based strategy to identify and integrate evidence from epidemiological,
, and
studies. The evidence from prospective epidemiological studies was quantitatively synthesized by meta-analysis. We rated the body of evidence and integrated the streams of evidence to systematically develop hazard identification conclusions.
We identified seven epidemiological studies reporting prospective associations between exposure to
-DDE and adiposity assessed by body mass index (BMI)
-score. The results from the meta-analysis revealed positive associations between exposure to
-DDE and BMI
-score (β=0.13 BMI
-score (95% CI: 0.01, 0.25) per log increase of
-DDE). Two studies constituted the primary
evidence. Both studies reported positive associations between exposure to
-DDT and increased adiposity in rodents. We identified 19
studies and 7
studies that supported the biological plausibility of the obesogenic effects of
-DDT and
-DDE.
We classified
-DDT and
-DDE as "presumed" to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary
evidence, and a moderate level of supporting evidence from
and
studies. https://doi.org/10.1289/EHP527.