Molecular cell, 2018-01, Vol.69 (1), p.100-112.e6
2018
Details
- Autor(en) / Beteiligte
- Titel
- Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response
- Ist Teil von
- Molecular cell, 2018-01, Vol.69 (1), p.100-112.e6
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- As sessile organisms, plants must adapt to variations in the environment. Environmental stress triggers various responses, including growth inhibition, mediated by the plant hormone abscisic acid (ABA). The mechanisms that integrate stress responses with growth are poorly understood. Here, we discovered that the Target of Rapamycin (TOR) kinase phosphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress response in unstressed plants. This phosphorylation disrupts PYL association with ABA and with PP2C phosphatase effectors, leading to inactivation of SnRK2 kinases. Under stress, ABA-activated SnRK2s phosphorylate Raptor, a component of the TOR complex, triggering TOR complex dissociation and inhibition. Thus, TOR signaling represses ABA signaling and stress responses in unstressed conditions, whereas ABA signaling represses TOR signaling and growth during times of stress. Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and stress responses. [Display omitted] •The TOR kinase phosphorylates ABA receptor PYLs at a conserved serine residue•PYLs phosphorylation inhibits stress responses by abolishing PYLs activities•Stress- and ABA-activated SnRK2s phosphorylate Raptor and inhibit TOR activity•TOR and ABA signaling balance plant growth and stress responses Wang et al. reveal that the TOR kinase phosphorylates ABA receptors to repress stress responses under unstressed conditions and to promote growth recovery once environmental stresses subside. Under stress conditions, SnRK2s phosphorylate Raptor, a regulatory component in the TOR complex, to prevent growth by inhibiting TOR activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-2765eISSN: 1097-4164DOI: 10.1016/j.molcel.2017.12.002Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5772982
- Format
- –
- Schlagworte
- ABA receptor, abscisic acid, Abscisic Acid - metabolism, Arabidopsis - growth & development, Arabidopsis Proteins - metabolism, Gene Expression Regulation, Plant - physiology, Phosphatidylinositol 3-Kinases - metabolism, Phosphorylation, Plant Growth Regulators - metabolism, Protein-Serine-Threonine Kinases - metabolism, Raptor, Receptors, Cell Surface - metabolism, Regulatory-Associated Protein of mTOR - metabolism, Signal Transduction, SnRK2, Stress, Physiological, Target of Rapamycin