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  • BibTeX
Congestive Heart Failure During Osimertinib Treatment for Epidermal Growth Factor Receptor (EGFR)-mutant Non-small Cell Lung Cancer (NSCLC)
Internal Medicine, 2017/08/15, Vol.56(16), pp.2195-2197
2017

Details

Autor(en) / Beteiligte
Titel
Congestive Heart Failure During Osimertinib Treatment for Epidermal Growth Factor Receptor (EGFR)-mutant Non-small Cell Lung Cancer (NSCLC)
Ist Teil von
  • Internal Medicine, 2017/08/15, Vol.56(16), pp.2195-2197
Ort / Verlag
Japan: The Japanese Society of Internal Medicine
Erscheinungsjahr
2017
Link zum Volltext
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
  • We herein report a case of congestive heart failure which developed during osimertinib treatment. A 78-year-old woman presented with mild exertional dyspnea three weeks after starting osimertinib for the treatment of epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer. She was diagnosed with congestive heart failure caused by the osimertinib. In contrast to trastuzumab, a human epidermal growth factor receptor 2 (HER2) monoclonal antibody that often causes cardiac dysfunction, the causal relationship between osimertinib and cardiotoxicity has so far received little attention and thus remains unclear. However, it inhibits HER2 in addition to mutant EGFR, thereby potentially causing cardiotoxicity.
Sprache
Englisch
Identifikatoren
ISSN: 0918-2918
eISSN: 1349-7235
DOI: 10.2169/internalmedicine.8344-16
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5596283
Format
–
Schlagworte
Acrylamides, Aged, Aniline Compounds, Antineoplastic Agents - adverse effects, Antineoplastic Agents - therapeutic use, Carcinoma, Non-Small-Cell Lung - drug therapy, Carcinoma, Non-Small-Cell Lung - genetics, Cardiotoxicity, Case Report, Case reports, Congestive heart failure, Dyspnea, Dyspnea - chemically induced, Epidermal growth factor, Epidermal growth factor receptors, ErbB Receptors - genetics, ErbB-2 protein, Female, Heart failure, Heart Failure - chemically induced, Heart Failure - diagnostic imaging, Humans, Internal medicine, Lung cancer, Lung Neoplasms - drug therapy, Lung Neoplasms - genetics, Monoclonal antibodies, Mutation, Non-small cell lung carcinoma, osimertinib, Piperazines - adverse effects, Piperazines - therapeutic use, Protein Kinase Inhibitors - adverse effects, Protein Kinase Inhibitors - therapeutic use, Radiography, Thoracic, Respiration, T790M, Targeted cancer therapy, Tomography, X-Ray Computed, Trastuzumab

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