Details

Autor(en) / Beteiligte

• Onami, Saeko
• Okubo, Chigusa
• Iwanaga, Asuka
• Suzuki, Hiroaki
• Iida, Hajime
• Motohashi, Yurie
• Tomonari, Yuki
• Otake, Seiji
• Tsuji, Hiroyuki
• Yoshimura, Hiroyuki

Titel

Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice

Ist Teil von

• Journal of Toxicologic Pathology, 2017, Vol.30(3), pp.209-216

Ort / Verlag

Japan: JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

Erscheinungsjahr

2017

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), three well-known lung carcinogens at high doses, has not been sufficiently reported in lower dose ranges. Our study evaluated the tumorigenicity of urethane, NNK, and B[a]P at 26 weeks after a single intraperitoneal administration of each compound within medium to low dose in male and/or female A/JJmsSlc (A/J) mice. Dose-dependent tumorigenesis was demonstrated histopathologically for the three compounds. These results suggested that the tumorigenicity of these chemicals is dose dependent in A/J mice, even at lower doses than previously reported.