Details

Autor(en) / Beteiligte

• Seghier, Mohamed L.
• Patel, Elnas
• Prejawa, Susan
• Ramsden, Sue
• Selmer, Andre
• Lim, Louise
• Browne, Rachel
• Rae, Johanna
• Haigh, Zula
• Ezekiel, Deborah
• Hope, Thomas M.H.
• Leff, Alex P.
• Price, Cathy J.

Titel

The PLORAS Database: A data repository for Predicting Language Outcome and Recovery After Stroke

Ist Teil von

• NeuroImage (Orlando, Fla.), 2016-01, Vol.124 (Pt B), p.1208-1212

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• The PLORAS Database is a relational repository of anatomical and functional imaging data that has primarily been acquired from stroke survivors, along with standardized scores on a wide range of sensory, motor and cognitive abilities, demographic details and medical history. As of January 2015, we have data from 750 patients with an expected accrual rate of 200 patients per year. Expansion will accelerate as we extend our collaborations. The main aim of the database is to Predict Language Outcome and Recovery After Stroke (PLORAS) on the basis of a single structural (anatomical) brain scan that indexes the stereotactic location and extent of brain damage. Predictions are made for individual patients by indicating how other patients with the most similar brain damage, cognitive abilities and demographic details recovered their language skills over time. Predictions are validated by longitudinal follow-ups of patients who initially presented with speech and language difficulties. The PLORAS Database can also be used to predict recovery of other cognitive abilities on the basis of anatomical brain scans. The functional imaging data can be used to understand the neural mechanisms that support recovery from brain damage; and all the data can be used to understand the main sources of inter-subject variability in structure–function mappings in the human brain. Data will be made available for sharing, subject to: funding, ethical approval and patient consent. •The PLORAS Database is a repository of data from hundreds of stroke patients.•Lesion site is identified from T1-weighted structural MRI scans.•Impairments are assessed using the Comprehensive Aphasia Test.•Functional MRI data are collected from 14 different speech and language tasks.•All data contribute to understanding and modeling inter-subject variability.