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Clinical relevance of copy number profiling in oral and oropharyngeal squamous cell carcinoma
Ist Teil von
Cancer medicine (Malden, MA), 2015-10, Vol.4 (10), p.1525-1535
Ort / Verlag
United States: John Wiley & Sons, Inc
Erscheinungsjahr
2015
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Current conventional treatment modalities in head and neck squamous cell carcinoma (HNSCC) are nonselective and have shown to cause serious side effects. Unraveling the molecular profiles of head and neck cancer may enable promising clinical applications that pave the road for personalized cancer treatment. We examined copy number status in 36 common oncogenes and tumor suppressor genes in a cohort of 191 oropharyngeal squamous cell carcinomas (OPSCC) and 164 oral cavity squamous cell carcinomas (OSCC) using multiplex ligation probe amplification. Copy number status was correlated with human papillomavirus (HPV) status in OPSCC, with occult lymph node status in OSCC and with patient survival. The 11q13 region showed gain or amplifications in 59% of HPV‐negative OPSCC, whereas this amplification was almost absent in HPV‐positive OPSCC. Additionally, in clinically lymph node‐negative OSCC (Stage I–II), gain of the 11q13 region was significantly correlated with occult lymph node metastases with a negative predictive value of 81%. Multivariate survival analysis revealed a significantly decreased disease‐free survival in both HPV‐negative and HPV‐positive OPSCC with a gain of Wnt‐induced secreted protein‐1. Gain of CCND1 showed to be an independent predictor for worse survival in OSCC. These results show that copy number aberrations, mainly of the 11q13 region, may be important predictors and prognosticators which allow for stratifying patients for personalized treatment of HNSCC.
Using copy number profiling, clinical relevant aberrations are identified for detection of occult nodal metastases and prediction of survival in oral and oropharyngeal squamous cell carcinoma. In addition, biological differences between human papillomavirus (HPV)‐positive and HPV‐negative oropharyngeal cancers are illustrated.