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Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis
Ist Teil von
The New England journal of medicine, 2014-10, Vol.371 (17), p.1577-1587
Ort / Verlag
Waltham, MA: Massachusetts Medical Society
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ）
Beschreibungen/Notizen
One approach to improving tuberculosis therapy is to shorten the duration from 6 months to 4 months. In this trial in over 1900 patients with smear-positive tuberculosis, two 4-month moxifloxacin-based regimens did not perform as well as the standard 6-month regimen.
A short-term tuberculosis treatment regimen could improve rates of adherence, reduce rates of adverse events, and lower costs. Fluoroquinolones have shown promising activity against mycobacteria
1
and are established as a critical component of the treatment of multidrug-resistant tuberculosis,
2
,
3
with later fluoroquinolones recognized as having a more potent effect. It has been proposed that these drugs may have a role in reducing the duration of tuberculosis treatment.
4
Moxifloxacin has been approved for a range of indications globally.
5
It has favorable pharmacokinetics, a large volume of distribution, and penetration into epithelial-lining fluid and macrophages.
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–
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The activity of moxifloxacin in vitro . . .