Angewandte Chemie (International ed.), 2009-01, Vol.48 (48), p.9097-9101
2009
Details
- Autor(en) / Beteiligte
- Titel
- Photochromic Blockers of Voltage-Gated Potassium Channels
- Ist Teil von
- Angewandte Chemie (International ed.), 2009-01, Vol.48 (48), p.9097-9101
- Ort / Verlag
- Weinheim: Wiley-VCH Verlag
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Light work: Studies into the mechanism of AAQ, a photoswitchable blocker of voltage‐gated K+ channels, led to the discovery and development of photochromic ligands that act at the internal tetraethylammonium binding site (see picture). These molecules can be applied from the extracellular side to impart long‐lasting photosensitivity on K+ channels in living cells and thereby afford photocontrol of action potential firing in neurons.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.200904504Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4040390
- Format
- –
- Schlagworte
- azo compounds, Binding Sites, Cell Line, Hippocampus - drug effects, Hippocampus - metabolism, Humans, ion channels, Isomerism, Ligands, Molecular Structure, open-channel block, Patch-Clamp Techniques, photochromism, Photosensitizing Agents - chemistry, Photosensitizing Agents - pharmacology, Potassium Channel Blockers - chemistry, Potassium Channel Blockers - pharmacology, Potassium Channels, Voltage-Gated - antagonists & inhibitors, Potassium Channels, Voltage-Gated - metabolism, Structure-Activity Relationship, structure-activity relationships