Details

Autor(en) / Beteiligte

• DALTON, Heather J
• ARMAIZ-PENA, Guillermo N
• GONZALEZ-VILLASANA, Vianey
• LOPEZ-BERESTEIN, Gabriel
• BAR-ELI, Menashe
• SOOD, Anil K

Titel

Monocyte Subpopulations in Angiogenesis

Ist Teil von

• Cancer research (Chicago, Ill.), 2014-03, Vol.74 (5), p.1287-1293

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2014

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Growing understanding of the role of the tumor microenvironment in angiogenesis has brought monocyte-derived cells into focus. Monocyte subpopulations are an increasingly attractive therapeutic target in many pathologic states, including cancer. Before monocyte-directed therapies can be fully harnessed for clinical use, understanding of monocyte-driven angiogenesis in tissue development and homeostasis, as well as malignancy, is required. Here, we provide an overview of the mechanisms by which monocytic subpopulations contribute to angiogenesis in tissue and tumor development, highlight gaps in our existing knowledge, and discuss opportunities to exploit these cells for clinical benefit.