Details

Autor(en) / Beteiligte

• Abel, Jean LeBeau
• Rissman, Emilie F.

Titel

Running-induced epigenetic and gene expression changes in the adolescent brain

Ist Teil von

• International journal of developmental neuroscience, 2013-10, Vol.31 (6), p.382-390

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• ► Neural gene expression profiles are influenced by exercise in male adolescent mice. ► Bdnf mRNA in the hippocampus increase is increased by adolescent exercise. ► Exercise enhances histone 3 acetylation in cerebellum and hippocampus. ► Genes coding for epigenetic enzymes decrease in expression in response to exercise. Physical exercise is associated with positive neural functioning. Here we examined the gene expression consequences of 1 week of voluntary wheel running in adolescent male mice. We assayed expression levels of genes associated with synaptic plasticity, signaling pathways, and epigenetic modifying enzymes. Two regions were examined: the hippocampus, which is typically examined in exercise studies, and the cerebellum, an area directly involved in motor control and learning. After 1 week of exercise, global acetylation of histone 3 was increased in both brain regions. Interestingly this was correlated with increased brain derived neural growth factor in the hippocampus, as noted in many other studies, but only a trend was found in cerebellum. Differences and similarities between the two areas were noted for genes encoding functional proteins. In contrast, the expression pattern of DNA methyltransferases (Dnmts) and histone deacetylases (Hdacs), genes that influence DNA methylation and histone modifications in general, decreased in both regions with exercise. We hypothesize that epigenetic mechanisms, involving many of the genes assessed here, are essential for the positive affects of exercise on behavior and suspect these data have relevance for adolescent boys.