Immunity (Cambridge, Mass.), 2013-02, Vol.38 (2), p.384-398
2013
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- Autor(en) / Beteiligte
- Titel
- The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors
- Ist Teil von
- Immunity (Cambridge, Mass.), 2013-02, Vol.38 (2), p.384-398
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Innate immunity conferred by the type I interferon is critical for antiviral defense. To date only a limited number of tripartite motif (TRIM) proteins have been implicated in modulation of innate immunity and anti-microbial activity. Here we report the complementary DNA cloning and systematic analysis of all known 75 human TRIMs. We demonstrate that roughly half of the 75 TRIM-family members enhanced the innate immune response and that they do this at multiple levels in signaling pathways. Moreover, messenger RNA levels and localization of most of these TRIMs were found to be altered during viral infection, suggesting that their regulatory activities are highly controlled at both pre- and posttranscriptional levels. Taken together, our data demonstrate a very considerable dedication of this large protein family to the positive regulation of the antiviral response, which supports the notion that this family of proteins evolved as a component of innate immunity. [Display omitted] ▸ Nearly half of all 75 TRIM protein family members are innate immune enhancers ▸ TRIM mRNA expression and protein localization are complexly regulated during infection ▸ TRIMs confer differential regulation in distinct innate immune signaling pathways
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1074-7613eISSN: 1097-4180DOI: 10.1016/j.immuni.2012.11.013Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3584420
- Format
- –
- Schlagworte
- Alternative Splicing, Bioinformatics, Carrier Proteins - antagonists & inhibitors, Carrier Proteins - genetics, Carrier Proteins - immunology, Cell Line, Cloning, Cloning, Molecular, Gene expression, Gene Expression Profiling, Gene Expression Regulation, Genotype & phenotype, Humans, Immune system, Immunity, Innate, Leukocytes, Mononuclear - immunology, Leukocytes, Mononuclear - metabolism, Leukocytes, Mononuclear - virology, Molecular weight, Plasmids, Protein Isoforms - antagonists & inhibitors, Protein Isoforms - genetics, Protein Isoforms - immunology, Proteins, Receptors, Pattern Recognition - genetics, Receptors, Pattern Recognition - immunology, Rhabdoviridae Infections - immunology, Rhabdoviridae Infections - metabolism, Rhabdoviridae Infections - virology, RNA, Messenger - genetics, RNA, Messenger - immunology, RNA, Small Interfering - genetics, Signal Transduction, Vesiculovirus - immunology, Zinc Fingers - genetics, Zinc Fingers - immunology