Details

Autor(en) / Beteiligte

• Chu, Chung-Ching
• Ali, Niwa
• Karagiannis, Panagiotis
• Di Meglio, Paola
• Skowera, Ania
• Napolitano, Luca
• Barinaga, Guillermo
• Grys, Katarzyna
• Sharif-Paghaleh, Ehsan
• Karagiannis, Sophia N
• Peakman, Mark
• Lombardi, Giovanna
• Nestle, Frank O

Titel

Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

Ist Teil von

• The Journal of experimental medicine, 2012-05, Vol.209 (5), p.935-945

Ort / Verlag

United States: The Rockefeller University Press

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood. In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs). CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation. Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs. These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity. These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity. Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.