Cold Spring Harbor perspectives in biology, 2011-07, Vol.3 (7), p.a004952-a004952
2011
Details
- Autor(en) / Beteiligte
- Titel
- Heparan sulfate proteoglycans
- Ist Teil von
- Cold Spring Harbor perspectives in biology, 2011-07, Vol.3 (7), p.a004952-a004952
- Ort / Verlag
- United States: Cold Spring Harbor Laboratory Press
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although few in number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1943-0264eISSN: 1943-0264DOI: 10.1101/cshperspect.a004952Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3119907
- Format
- –
- Schlagworte
- Cell Adhesion, Cell Differentiation, Cell Movement, Chemokines - metabolism, Endocytosis, Extracellular Matrix - metabolism, Heparan Sulfate Proteoglycans - chemistry, Heparan Sulfate Proteoglycans - metabolism, Heparan Sulfate Proteoglycans - physiology, Ligands, Models, Biological, Mutation, Receptors, Cell Surface - chemistry, Receptors, Cell Surface - metabolism, Receptors, Cell Surface - physiology, Stem Cells - cytology, Substrate Specificity