UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Universitätsbibliothek
Katalog
Details
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Datensatz exportieren als...
BibTeX
Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children
Pediatric pulmonology, 2011-01, Vol.46 (1), p.83-91
Rosa, Maria José
Divjan, Adnan
Hoepner, Lori
Sheares, Beverley J.
Diaz, Diurka
Gauvey-Kern, Kevin
Perera, Frederica P.
Miller, Rachel L.
Perzanowski, Matthew S.
2011
Details
Autor(en) / Beteiligte
Rosa, Maria José
Divjan, Adnan
Hoepner, Lori
Sheares, Beverley J.
Diaz, Diurka
Gauvey-Kern, Kevin
Perera, Frederica P.
Miller, Rachel L.
Perzanowski, Matthew S.
Titel
Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children
Ist Teil von
Pediatric pulmonology, 2011-01, Vol.46 (1), p.83-91
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
Objectives and Hypothesis To determine the feasibility of using a multiple flow offline fractional exhaled nitric oxide (FeNO) collection method in an inner‐city cohort and determine this population's alveolar and conducting airway contributions of NO. We hypothesized that the flow independent NO parameters would be associated differentially with wheeze and seroatopy. Methods As part of a birth cohort study, 9‐year‐old children (n = 102) of African‐American and Dominican mothers living in low‐income NYC neighborhoods had FeNO samples collected offline at constant flow rates of 50, 83, and 100 ml/sec. Seroatopy was defined as having measurable (≥0.35 IU/ml) specific IgE to any of the five inhalant indoor allergens tested. Current wheeze (last 12 months) was assessed by ISAAC questionnaire. Bronchial NO flux (JNO) and alveolar NO concentration (Calv) were estimated by the Pietropaoli and Hogman methods. Results Valid exhalation flow rates were achieved in 96% of the children. Children with seroatopy (53%) had significantly higher median JNO (522 pl/sec vs. 161 pl/sec, P < 0.001) when compared to non‐seroatopic children; however, median Calv was not significantly different between these two groups (5.5 vs. 5.8, P = 0.644). Children with wheeze in the past year (21.6%) had significantly higher median Calv (8.4 ppb vs. 4.9 ppb, P < 0.001), but not JNO (295 pl/sec vs. 165 pl/sec, P = 0.241) when compared with children without wheeze. These associations remained stable after adjustment for known confounders/covariates. Conclusions The multiple flow method was easily implemented in this pediatric inner‐city cohort. In this study population, alveolar concentration of NO may be a better indicator of current wheeze than single flow FeNO. Pediatr Pulmonol. 2011; 46:83–91. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-6863
eISSN: 1099-0496
DOI: 10.1002/ppul.21328
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3056274
Format
–
Schlagworte
Allergens - immunology
,
alveolar NO
,
Alveolar NO concentration
,
asthma
,
Asthma - epidemiology
,
atopy
,
Biological and medical sciences
,
Breath Tests - methods
,
bronchial flux
,
Calv
,
Calv, Alveolar NO concentration
,
Child
,
Chronic obstructive pulmonary disease, asthma
,
Cohort Studies
,
Exhalation - physiology
,
Female
,
FeNO
,
FeNO, Fractional exhaled nitric oxide
,
FeNO50
,
FeNO50, Fractional exhaled nitric oxide collected at 50 ml/sec
,
Fractional exhaled nitric oxide
,
Fractional exhaled nitric oxide collected at 50 ml/sec
,
General aspects
,
Humans
,
Immunoglobulin E - blood
,
JNO
,
JNO, Total NO bronchial flux
,
Male
,
Medical sciences
,
New York City
,
Nitric Oxide - physiology
,
offline FeNO method
,
Pneumology
,
Poverty
,
Pulmonary Gas Exchange - physiology
,
Respiratory Sounds - diagnosis
,
Respiratory Sounds - physiopathology
,
Total NO bronchial flux
,
Urban Population
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX