Details

Autor(en) / Beteiligte

• Kuilman, Thomas
• Michaloglou, Chrysiis
• Mooi, Wolter J
• Peeper, Daniel S

Titel

The essence of senescence

Ist Teil von

• Genes & development, 2010-11, Vol.24 (22), p.2463-2479

Ort / Verlag

United States: Cold Spring Harbor Laboratory Press

Erscheinungsjahr

2010

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.