Nature reviews. Genetics, 2007-09, Vol.8 (9), p.699-710
2007
Details
- Autor(en) / Beteiligte
- Titel
- Integrating physical and genetic maps: from genomes to interaction networks
- Ist Teil von
- Nature reviews. Genetics, 2007-09, Vol.8 (9), p.699-710
- Ort / Verlag
- London: Nature Publishing Group
- Erscheinungsjahr
- 2007
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Physical and genetic mapping data have become as important to network biology as they once were to the Human Genome Project. Integrating physical and genetic networks currently faces several challenges: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. A particular challenge involves reconciling the wide variety of interaction types that are currently available. For this purpose, recent studies have sought to classify genetic and physical interactions along several complementary dimensions, such as ordered versus unordered, alleviating versus aggravating, and first versus second degree.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-0056eISSN: 1471-0064DOI: 10.1038/nrg2144Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2811081
- Format
- –
- Schlagworte
- Automation, Biological and medical sciences, Chromosome mapping, Chromosomes, Classical genetics, quantitative genetics, hybrids, Cloning, DNA sequencing, Fundamental and applied biological sciences. Psychology, Gene Regulatory Networks, Genes, Genetic epistasis, Genetic markers, Genetic Techniques, Genetics, Genetics of eukaryotes. Biological and molecular evolution, Genome, Human, Genomes, Genomics, Genotype & phenotype, Humans, Methods, theories and miscellaneous, Models, Biological, Mutation, Nucleotide sequencing, Physical Chromosome Mapping, Physiological aspects, Proteins, Radiation, Signal transduction, Signal Transduction - genetics