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Dicer and Drosha are RNase enzymes involved in RNA interference from precursor molecules. RNA interference can either silence or enhance the expression of specific target genes. This study of ovarian-cancer cells showed that the combination of low Dicer expression and low Drosha expression was associated with a poor prognosis and that low Dicer expression was an independent factor associated with a poor clinical outcome.
Dicer and Drosha are RNase enzymes involved in RNA interference from precursor molecules. This study of ovarian-cancer cells showed that the combination of low Dicer expression and low Drosha expression was associated with a poor prognosis and that low Dicer expression was an independent factor associated with a poor clinical outcome.
The discovery that gene expression can be altered through RNA interference
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has stimulated research on the role of RNA interference in the development of cancer. Targeting specific genes by RNA-interference molecules allows for the identification of regulators of angiogenic, proliferative, and survival pathways in cancer cells. Furthermore, RNA-interference molecules that silence specific genes are being tested in preclinical studies as a treatment for cancer.
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Regulation of gene expression through RNA interference occurs by means of microRNA (miRNA) or small interfering RNA (siRNA) (Figure 1). In the nucleus, endogenous double-stranded RNA segments are cut into short, hairpin-shaped double-stranded RNA precursor . . .