Details

Autor(en) / Beteiligte

• Mamì, C
• Manganaro, R
• Marseglia, L
• Saitta, G
• Gemelli, M
• Martino, F

Titel

Plasma leptin, insulin, and neuropeptide Y response to feeding in newborn infants

Ist Teil von

• Archives of disease in childhood. Fetal and neonatal edition, 2006-09, Vol.91 (5), p.F389-F389

Ort / Verlag

England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health

Erscheinungsjahr

2006

Link zum Volltext

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• In adult humans, plasma leptin concentrations do not change in response to meals, suggesting that, in the regulation of energy balance, leptin works as a long term adiposity signal rather than a short term meal related factor. 4 The discovery that the stomach can also produce and store leptin and release it in response to food intake has suggested that leptin may also have a role in the short term control of energy balance. 5, 6 Recently, it has been shown that the onset of leptin mRNA expression and leptin synthesis in the human stomach takes place around the 11th week and increases sharply in older fetuses. 7 Moreover, in neonatal rats, it has been shown that orally supplied leptin is directly taken up by the immature stomach and may regulate short term feeding. 8 The early post-feeding increase in plasma concentrations of leptin, observed by us, in agreement with Cinaz et al, 2 may suggest that the neonate adsorbs leptin produced by the gastric mucosa.