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London: BMJ Publishing Group Ltd and British Society of Gastroenterology
Erscheinungsjahr
2006
Link zum Volltext
Quelle
BMJ Journals Archiv - DFG Nationallizenzen
Beschreibungen/Notizen
The importance of epithelial barrier function in normal homeostasis can be appreciated from experiments performed in the early 1990s where cell wall extracts from luminal bacteria were injected into the colonic wall of rats. 1 This simple manoeuvre of bypassing the epithelial barrier and placing luminal compounds directly into the colonic wall initiated an inflammatory disease that was characterised by granulomatous reactions both in the bowel and, importantly, as a systemic inflammatory process. The strongest association is with Campylobacter infections and in this condition increased permeability can be observed up to a year following infection. 96 In another large study involving IBS following a waterborne outbreak of gastroenteritis, increased permeability was more commonly observed in patients with IBS than controls. 97 These studies provide intriguing data that abnormal permeability may be involved in disease pathogenesis, although they cannot exclude an alternative explanation that mild gut damage (measured by increased permeability) is associated with the development of IBS by another mechanism.