Details

Autor(en) / Beteiligte

• Krogsaeter, Einar
• Tang, Rachel
• Grimm, Christian

Titel

JPT2: The missing link between intracellular Ca 2+ release channels and NAADP?

Ist Teil von

• Cell calcium (Edinburgh), 2021-04, Vol.97, p.102405

Ort / Verlag

Netherlands

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent second messenger releasing Ca from endolysosomes through two-pore channels (TPCs) and from the endoplasmic reticulum (ER) through type 1 ryanodine receptors (RyR1). How NAADP activates these channels, whether directly or indirectly, has been a matter of debate for more than a decade. Now a protein has emerged possibly providing the missing link between TPCs/RyR1 and NAADP.