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Emerging therapies for inv(16) AML
Blood, 2021-05, Vol.137 (19), p.2579-2584
2021

Details

Autor(en) / Beteiligte
Titel
Emerging therapies for inv(16) AML
Ist Teil von
  • Blood, 2021-05, Vol.137 (19), p.2579-2584
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2021
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
  • The core binding factor composed of CBFβ and RUNX subunits plays a critical role in most hematopoietic lineages and is deregulated in acute myeloid leukemia (AML). The fusion oncogene CBFβ-SMMHC expressed in AML with the chromosome inversion inv(16)(p13q22) acts as a driver oncogene in hematopoietic stem cells and induces AML. This review focuses on novel insights regarding the molecular mechanisms involved in CBFβ-SMMHC–driven leukemogenesis and recent advances in therapeutic approaches to target CBFβ-SMMHC in inv(16) AML. [Display omitted]
Sprache
Englisch
Identifikatoren
ISSN: 0006-4971
eISSN: 1528-0020
DOI: 10.1182/blood.2020009933
Titel-ID: cdi_pubmed_primary_33821975
Format
–
Schlagworte
Animals, Antineoplastic Agents, Immunological - therapeutic use, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Cell Transformation, Neoplastic - genetics, Chromosome Inversion, Chromosomes, Human, Pair 16 - genetics, Chromosomes, Human, Pair 16 - ultrastructure, Combined Modality Therapy, Core Binding Factor Alpha 2 Subunit - deficiency, Core Binding Factor Alpha 2 Subunit - metabolism, Core Binding Factor beta Subunit - genetics, Core Binding Factor beta Subunit - physiology, Forecasting, Gemtuzumab - therapeutic use, Gene Expression Regulation, Leukemic, Gene Knock-In Techniques, Hematopoiesis - drug effects, Hematopoiesis - genetics, Humans, Immunotherapy - methods, Leukemia, Myeloid, Acute - drug therapy, Leukemia, Myeloid, Acute - genetics, Mice, Molecular Targeted Therapy, Myosin Heavy Chains - genetics, Neoplastic Stem Cells - drug effects, Neoplastic Stem Cells - metabolism, Neoplastic Stem Cells - pathology, Oncogene Proteins, Fusion - antagonists & inhibitors, Oncogene Proteins, Fusion - genetics, Oncogene Proteins, Fusion - physiology, Spotlight, T-Lymphocytes - immunology, Xenograft Model Antitumor Assays

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