Details

Autor(en) / Beteiligte

• Devi, Sharmila

Titel

Research brief

Ist Teil von

• The Lancet infectious diseases, 2021-03, Vol.21 (3), p.327-327

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

2021

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Scans of ZIKV-positive brains collected in Brazil during the 2015–16 Zika outbreak revealed that cells called pericytes, which wrap around blood capillaries in the brain, collect around calcified lesions and have high concentrations of viral genetic material, suggesting a key role in infection-induced calcification. Antibody against dengue An antibody that blocks the spread of the dengue virus, a mosquito-borne pathogen that infects between 50 and 100 million people a year, within the body has been discovered. Since there are four different serotypes of the virus, building up antibodies against one strain can actually leave people more vulnerable to subsequent infection from another strain, which makes finding an effective therapeutic more difficult. The research team's antibody, called 2B7, physically blocks the NS1 protein used by the dengue virus to bind to human cells. [...]because the antibody attacks the protein directly and not the virus particle itself, 2B7 is effective against all four serotypes of the dengue virus.