Details

Autor(en) / Beteiligte

• Velthorst, Eva
• Mollon, Josephine
• Murray, Robin M
• de Haan, Lieuwe
• Germeys, Inez Myin
• Glahn, David C
• Arango, Celso
• van der Ven, Els
• Di Forti, Marta
• Bernardo, Miguel
• Guloksuz, Sinan
• Delespaul, Philippe
• Mezquida, Gisela
• Amoretti, Silvia
• Bobes, Julio
• Saiz, Pilar A
• García-Portilla, María Paz
• Santos, José Luis
• Jiménez-López, Estela
• Sanjuan, Julio
• Aguilar, Eduardo J
• Arrojo, Manuel
• Carracedo, Angel
• López, Gonzalo
• González-Peñas, Javier
• Parellada, Mara
• Atbaşoğlu, Cem
• Saka, Meram Can
• Üçok, Alp
• Alptekin, Köksal
• Akdede, Berna
• Binbay, Tolga
• Altınyazar, Vesile
• Ulaş, Halis
• Yalınçetin, Berna
• Gümüş-Akay, Güvem
• Beyaz, Burçin Cihan
• Soygür, Haldun
• Cankurtaran, Eylem Şahin
• Kaymak, Semra Ulusoy
• Maric, Nadja P
• Mihaljevic, Marina M
• Petrovic, Sanja Andric
• Mirjanic, Tijana
• Del-Ben, Cristina Marta
• Ferraro, Laura
• Gayer-Anderson, Charlotte
• Jones, Peter B
• Jongsma, Hannah E
• Kirkbride, James B
• La Cascia, Caterina
• Lasalvia, Antonio
• Tosato, Sarah
• Llorca, Pierre-Michel
• Menezes, Paulo Rossi
• Morgan, Craig
• Quattrone, Diego
• Menchetti, Marco
• Selten, Jean-Paul
• Szöke, Andrei
• Tarricone, Ilaria
• Tortelli, Andrea
• McGuire, Philip
• Valmaggia, Lucia
• Kempton, Matthew J
• van der Gaag, Mark
• Riecher-Rössler, Anita
• Bressan, Rodrigo A
• Barrantes-Vidal, Neus
• Nelson, Barnaby
• McGorry, Patrick
• Pantelis, Chris
• Krebs, Marie-Odile
• Ruhrmann, Stephan
• Sachs, Gabriele
• Rutten, Bart P F
• van Os, Jim
• Alizadeh, Behrooz Z
• van Amelsvoort, Therese
• Bartels-Velthuis, Agna A
• Bruggeman, Richard
• van Beveren, Nico J
• Luykx, Jurjen J
• Cahn, Wiepke
• Simons, Claudia J P
• Kahn, Rene S
• Schirmbeck, Frederike
• van Winkel, Ruud
• Reichenberg, Abraham

Titel

Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Ist Teil von

• Molecular psychiatry, 2021-08, Vol.26 (8), p.4529-4543

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders.